Ahmad’s Project on 1LRV |
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 Figure
1:1LRV is unique for being leucine-rich.The
illustration has leucine compounds colored in blue.It
is composed of several alpha helices red.The
structure is also unique for its core 4Fe:4S (sulfur colored in green). |
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Protein
Information
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1 LRV is
a leucine-rich repeat variant, which is said to be found in the micro organism
azotobacter vinelandii.It consists of a two domain structure containing
a cluster of four cycsteine residues with 8 tandem repeats of 24 amino
acids.It also has a single 4Fe:4S cluster that is highly sensitive to oxygen.It
is similar to the class of Leucine-rich repeat proteins (LRR),A key difference,
however, is that 1LRV contains a-
and 310 helices arranged in a superhelix with the complete absense
of of any b-sheet
structure.The presence of which is very common in the LRR class.
When many
1LRV units form together, the Leucine contribute to the hydrophobic core
of the protein.The 4Fe:4S cluster is exposed to the solvent which probably
contributes to the protein’s sensitivity to oxygen.This cluster could act
as a biosensor like in regulatory proteins.
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