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Sequence

Modeling the Secondary Structure...

Backbone 
Comparing it to the Protein Dossier

Modeling selected Tiertiary Structures...
Alpha Helices 
Beta Sheets 
Hydrophobic structure 
Aliphatic structure 
Acyclic structure

Selected Domains in Tyrosine Kinase...
4 Structural Domains
Catalytic Domains - "Active Site"

Reading the PDB Reference Link for Tyrosine Kinase...
Tyrosine Kinase PDB Profile and Attribute Information

Perusing the NCBI Reference Links for Tyrosine Kinase...
GenBank
MMDB Structure Summary
OMIM
Locus Link
SwissProt
UniGene

PubMed Abstracts Related to Tyrosine Kinases 
Inhibition of SRC kinases by a selective tyrosine kinase inhibitor causes... 
Tyrosine Kinase signaling Breast Cancer
Cancer and Tyrosine Phosphorylation
Characterization of human epidermal growth factor receptor and c-Src....

Traversing CATH Reference Links...

Homologous Superfamily
Sequence Family
Identical Relatives
Non-identical relatives - Conserved Conformations

Scouring SCOP

Structural Classification of Proteins
Direct Link

Scanned the CMBI WHATIF Check Report
Found the Centre for Molecular Biomolecular Infomatics site from PDBSum where I found some notes about tyrosine kinase's potential deviations that would impact the interpretation of the structure. This database is used for Homology Modeling and functions to detect mutant prediction and structure verification. The records also include geometric uncertainties like bad or erroneous torsion angle which could vitiate structural comparisons. WHAT IF notes breaksdown potential warnings in an outline to review. Also displays a Ramachandran plot of the selected protein as well as RMS Inside/Outside z-Plot score.

Direct Link to WHAT IF Check Report  

Using GlaxoSmithKline DeepView / Swiss-PdbViewer
Found and downloaded this versatile tool that made it easy to load a pdb file and tweak its structure. It warned that the structure file has some missing side chains - something that was overlooked in Rasmol. This application is more robust because it has the ability to color force field energy, threading energy; it can also fix selected side chains.

DeepView screenshots


Using Molmovdb...
Downloaded the animated gifs for my pet protein from the Database of MacroMolecular Movements which contain a library of protein motions.

Morphing Motions
Rankable Stats

Searching the Enzyme Structure Database (ESDB)
As well as using NCBI's EC (Enzyme Classification) tool and came across ESDB classification database that proved equally useful in hunting through the layers of enzymes classification groups.  The database contains known enzyme structures stored in PDB at Brookhaven. Just like EC a ESDB using a Enzyme Classification number.  For Tyrosine Kinase, this number is:  EC2.7.1.112.

Direct Link to Enzyme Class for Tyrosine Kinase

Investigating the EMBL-EBI database
Using the Fold classification based on Structure-Structure alignment of Proteins (FSSP) I came across 65 matches when searching for Tyrosine Kinase. FSSP is an all-to-all 3D structural comparison database that uses the DALI search engine to process the searches.

Direct Link to Protein Index page search results from FSSP


Also checked out EMBL-EBI's MSD
Searched EBI and found the link to MSD (Macromolecular Structure Database) and looked at the likely quartenary structure or macromolecular assembly for Tyrosine Kinase. It summarizes the information in a test for crystal packing.

Direct Link to MSD Tyrosine Kinase record entry


Searching in the ExPaSy databases  
Started using Enzyme Commission Classification Scheme (PROWL) which linked me to ExPaSy database. After selecting the correct class and group, I then checked ExPasy's NiceZyme view to compare entries in the ESDB database to determine other cross references. This is the results I got when performing a search:

Direct Link to NiceZyme View  

Visted the WIS Bioinformatics site
This site maintained by the Weizmann Institute of Science, Bioinformatics and Biological Computing department is a site which also a good resource for finding relevant sites. This site maintained information found in most of the other sites but formatted differently. I easily found my ligand for my protein at this site.

Link to WIS information on 1FMK


Downloadable Tyrosine Kinase Literature and Documents

3D Structure of Tyrosine Kinase Protein Tyrosine Kinase, Promega
Signal Transduction and Revesible Transduction
Flickerbook page from Molmovdb
Alignment of Protein Structures from Amino Acids in their SEQRES decks