Introduction to Bioinformatics

What is Bioinformatics?

What is Computational Biology?

What’s in it for me?

What’s in it for me? [2]

What’s NOT in it for me?

Course Schedule

More on Bioinformatics

Components of Bioinformatics

What Data???

Sequence - DNA

Sequence - RNA

Sequence - Proteins

Sequences - Information Growth

Sequences - Genomes

Sequences - Genomes [2]

Structural Information - Data Growth

Bioinformatics challenges

Is this really Bioinformatics?

Is this really Bioinformatics? [2]

Is this really Bioinformatics? [3]

Major Application Areas

Introduction to NCBI’s Entrez

Introduction to NCBI’s Entrez [2]

Database Structure

Database Structure [2]

Database Structure [3]

Basic Searching

Using neighbors

Details, Limits, Preview et al.

Entrez qualifiers

Entrez qualifiers [2]

Advanced boolean searches

Exercises

Introduction to BLAST

Databases & Data Formats

Available search tools

Available search tools [2]

The BLAST family

GenBank Databases

The BLAST algorithm

Buyer Beware!

PPT Slide

BLAST With Small Sequences

VecScreen

VecScreen Details

Why use VecScreen?

Limitations of VecScreen

Exercise