Final Exam for Introduction to Bioinformatics

Please email the answers to

helgew@sdsc.edu by 5pm Friday, February 23, 2001.

Late submissions will NOT be accepted.

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    The following questions are about the human dopamine receptor D3

  1. What is/are the GenBank Accession number(s) for it's mRNA(s)?
  2. Which human chromosome is this receptor located on?
  3. What is its LocusID?
  4. What is its UniGene #'s?
  5. Which disease is treated with drugs that interact with this receptor?
  6. Using more than one information source, identify the protein family this receptor belongs to. What information sources have you used?
  7. Are there any known structures for this receptor? Identify any related structures using the PDB site and list their PDB Ids.
  8. Look at the structures you identified in 7 and compare them with the transmembrane prediction server results. How many transmembrane regions are there?
  9. The following sequence has a problem with it. Using the tools available at NCBI, identify what the problem is.

    TCGGCCATCGTCCATCTCATCAACTACCAGGATGATGCAGAGCTGGCCACCCGGGCTCTGCCTGAGCTCA CCAAGCTGCTCAACGATGAGGACCCGGTAGTGGTGACCAAGGCGGCTATGATCGTGAACCAGCTGTCCAA GAAGGAGGCATCCCGCCGGGCTCTAATGGGCTCGCCCCAGCTGGTGGCGGCGGTGGTGCGGACTATGCAG AACACCAGTGACCTGGATACTGCCCGGTGTACCACCAGCATCCTGCACAACCTCTCTCACCACCGAGAGG GCTTGCTCGCCATATTCAAGTCTGGAGGCATCCCTGCCCTAGTCCGAATGCTCAGTTCCCCCGTAGAATC TGTCCTGTTCTACGCCATCACCACACTGCACAACCTGCTGCTCTATCAGGAGGGCGCCAAGATGGCGGTG CGTCTGGCAGACGGGCTGCAGAAGATGGTGCCCCTACTCAACAAGAACAACCCTAAGTTCCTGGCCATCA CTACTGACTGCCTGCAGCTCCTGGCCTATGGCAACCAGGAGAGCAAGCTGATCATCCTGGCCAATGGGGG ACCCCAAGGGCTTGTGCAGATCATGAGGAACTACAGCTACGAGAAGCTTCTGTGGACCACCAGCCGTGTG CTCAAGGTGCTCTCCGTGTGTCCTAGCAACAAGCCCGCCATCGTGGAGGCTGGTGGGATGCAGGCTCTGG GCAAGCACTTGACAAGCAACAGTCCCCGCCTGGTGCAGAACTGCCTGTGGACTCTGCGCAATCTCTCGGA TGTAGCCACCAAGCAGGAGGGCCTGGAGAGTGTGCTGAAGATCCTGGTCAACCAACTGAGTGTAGATGAC GTCAACGTCCTCACCTGTGCCACGGGCACCCTCTCCAACCTGACCTGCAACAACAGCAAAAACAAGACGC TGGTGACACAGAACAGTGGCGTGGAGGCGCTCATCCACGCCATCCTGAGAGCCGGAGACAAAGATGACAT CACAGAGCCCGCTGTCTGTGCCCTGCGCCACCTTACCAGCCGTCACCCCGAGGCTGAGATGGCCCAGAAC TCTGTGCGCCTCAACTATGGAATCCCGGCCATTGTGAAACTGCTCAACCAGCCAAACCAGTGGCCACTGG TCAAGGCAACTATTGGCCTGATCCGGAACCTGGCTCTGTGCCCAGCCAACCATGCCCCTCTGCAGGAGGC CGCGGTCATTCCCCGCCTCGTCCAGCTGTTGGTCAAGGCCCACCAGGACGCCCAGCGCCATGTGGCTGCA GGCACCCAGCAGCCCTACACGGATGGTGTGAGGATGGAGGAGATCGTGGAAGGCTGCACCGGAGCCCTGC ACATCCTCGCCCGGGATCCCATGAACCGCATGGAGATCTTCCGGCTCAATACCATTCCCCTGTTTGTCCA GCTCCTGTACTCCTCTGTGGAGAACATCCAGCGTGTGGCTGCGGGAGTGCTCTGCGAGCTGGCCCAGGAC AAGGAGGCTGCCGACGCCATTGATGCGGAGGGCGCCTCTGCCCCTCTCATGGAGCTACTCCATTCCCGCA ATGAGGGCACCGCGACCTACGCTGCTGCTGTCCTGTTCCGCATCTCTGAGGACAAGAACCCAGATTACCG TAAGCGAGTGTCTGTGGAGCTCACCAATTCCCTCTTCAAGCATGACCCAGCTGCCTGGGAGGCTGCCCAG AGTATGATCCCGATCAACGAACCCTATGCAGACGACATGGATGCCACCTACCGCCCCATGTACTCCAGCG ATGTGCCTCTGGACCCTCTGGACATGCACATGGACCTGGATGGAGACTACCCCATGGACACCTACAGTGA CGGCCTGAGGCCTCCCTACCCCACTGCAGACCACATGCTGGCCTAGCAGCTCCACCTAAAAACGACGGCC AGTGAATTGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGGCGGC

  10. The protein sequence translated from the above NA sequence is closely related to a Drosophila protein. Which?